in silico Mathematical Modeling of the liver
in silico Mathematical Modeling of the liver
Our laboratory is also engaged in systems biology research using in silico methods[1].
In these topics, the metabolic pathways within hepatocytes and interactions between cells are
simulated and analyzed through the construction of ODE models (Ordinary Differential Equation models) and ABM (Agent-based models)[2].
We aim to gain new insights into the treatment of liver diseases such as MASLD[3] and liver fibrosis
through the approach using mathematical models.
Additionally, we focus on the interactions between pharmaceuticals, such as APAP, and intracellular metabolism,
as well as the effects of metabolic differences based on the position within the liver lobule, known as "metabolic zonation".
[1] Research using simulations and computational models.
[2] A modeling approach that simulates the behavior of individual agents (such as cells) to analyze and predict the overall dynamics.
[3] Metabolic dysfunction Associated Steatotic Liver Disease
