Development of advanced cell-based assays and their applications to efficacy/hazard evaluations
Development of advanced cell-based assays
and their applications to efficacy/hazard evaluations
[ Person in charge ]
Prof. Y.Sakai, Assist Prof. K.Komori, Project Assist Prof. N.Kojima,
Dr. K.Iwasawa, Dr. H.Matsui (BEANS Project), Dr. M.M.Chowdhury,
Ms. M.Shinohara (DC), Ms. W.Xiao (DC)
[ Collaborators ]
Prof. T,Fujii (IIS), Prof. T.Tatsuma (IIS), Assoc. Prof. S.Takeuchi (IIS),
Prof. A. Miyajima (IMCB), Dr. T.Ochiya (National Cancer Institute),
Assoc. Prof. T.Itoh (CDBIM, Graduate School of Medicine),
[ Content ]
Conventional 2D culture using tissue culture plates are sometimes not suitable for evaluating organ-specific functions under normal or stimulated conditions. Therefore, we have been investigating advanced organ/tissue models for future cell-based toxicological and pharmacological assays through the integration of 3D culture with suitable mass transfer, microfluidics, micropatterning, advanced sensing principles, etc. We are now focusing on advanced experimental models for the liver and lung alveolus tissues and also their use with multi-scale numerical simulation for animal-free drug efficacy predictions.
