In vitro organization and growth of implantable liver and pancreas beta-cell tissues
In vitro organization and growth of
implantable liver and pancreas beta-cell tissues
[ Person in charge ]
Prof. Y.Sakai, Assist Prof. K.Komori, Assist Prof. Dr. N.Kojima,
Mr. I.Sei (Hogy Medical Co. Ltd), Dr. T.Katsuda, Ms. Y.Pang (DC), S.Sutoko (MS)
[ Collaborators ]
Prof. T.Niino (IIS), Prof. Shirakashi (IIS), Dr. T.Ochiya (National Cancer Institute),
Assoc. Prof. T.Itoh (CDBIM, Graduate School of Medicine)
[ Content ]
It is necessary to integrate various knowledge and technologies ranging from basic biology and advanced engineering to clinical medicine in order to produce implantable organ/tissue equivalents in the future. As a chemical engineer, we have been trying to propose a design for multi-scale optimization of oxygenation to cells. On the basis of such fundamental design, we have been making biodegradable 3D scaffolds comprising of 3D branching/joining flow channels, effective 3D culture of hepatocyte progenitors, and artificial oxygen carriers for perfusion culture, based on various collaborations with experts.
